The novel arylamidine T-2307 maintains in vitro and in vivo activity against echinocandin-resistant Candida albicans.
نویسندگان
چکیده
We evaluated the in vitro and in vivo activities of the investigational arylamidine T-2307 against echinocandin-resistant Candida albicans. T-2307 demonstrated potent in vitro activity, and daily subcutaneous doses between 0.75 and 6 mg/kg of body weight significantly improved survival and reduced fungal burden compared to placebo control and caspofungin (10 mg/kg/day) in mice with invasive candidiasis caused by an echinocandin-resistant strain. Thus, T-2307 may have potential use in the treatment of echinocandin-resistant C. albicans infections.
منابع مشابه
In Vitro and In Vivo Antifungal Activities of T-2307, a Novel Arylamidine
The in vitro and in vivo antifungal activities of T-2307, a novel arylamidine, were evaluated and compared with those of fluconazole, voriconazole, micafungin, and amphotericin B. T-2307 exhibited broad-spectrum activity against clinically significant pathogens, including Candida species (MIC range, 0.00025 to 0.0078 g/ml), Cryptococcus neoformans (MIC range, 0.0039 to 0.0625 g/ml), and Aspergi...
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 59 2 شماره
صفحات -
تاریخ انتشار 2015